Denham Springs is situated at the intersections of the east-west highways, US 190 and Interstate 12, with La. Hwy. 16, the major north-south artery in western Livingston Parish. Denham Springs is also located on the Illinois Central Gulf Railroad, a line which played a large role in the city's early development. The Amite River also forms a portion of the municipality's boundary, but the river is not navigable at this point. Ground-water springs which come to the surface at the base of the low-lying ridge which runs through the center of the city have figured in the city's name since at least the 1850s.
A state of emergency was declared in mid-August when waters began rising in rivers, lakes, and bayous all across the southern area of the state. Denham Springs took much of the damage. 90% of the homes in Greater Baton Rouge were either damaged or destroyed. The Amite River, the main body of water in Denham Springs, was one of the most publicized rivers that flooded.
Downtown Denham Springs has transformed itself from hardware stores, drug stores, doctors' offices, and a single movie theater, into a collection of unique antique shops, and boutiques, including the locally popular restaurants and Cafes. The historic downtown district is now recognized as a cultural arts district and is known as the Denham Springs Antique Village